Originally published in 1925, after three years of anticipation, the book follows the life of Martin Arrowsmith, a rather ordinary fellow who gets his first taste of medicine at 14 as an assistant to the drunken physician in his home town.

It is Leora Tozer who makes Martin's life extraordinary. With vitality and love, she urges him beyond the confines of the mundane to risk answering his true calling as a scientist and researcher. Not even her tragic death can extinguish her spirit or her impact on Martin's life.

After years of work as a small town doctor and a research scientist, Arrowsmith heads for the West Indies with a serum to halt an epidemic. A tragic turn of events forces him to come to terms with his career and his personal life.

As the son and grandson of physicians, Sinclair Lewis had a store of experiences and imparted knowledge to draw upon for Arrowsmith.