Correspondence, speeches and writings, legal and financial papers, printed matter, and other papers relating to Hamilton's personal life and public career, especially his service as an aide to Gen. George Washington during the Revolutionary War, his participation in the Continental Congress and the Constitutional Convention, his service as secretary of the treasury, his New York law practice, and his service as inspector general of the army. Subjects include economic issues such as public finance, creation of a national bank, establishment of a mint, development of manufacturing, and the Society for Establishing Useful Manufactures; U.S. relations with France and Great Britain; legal cases before the New York Supreme Court; and the Hamilton, McLane (McLean), Schuyler, and Church families.

Correspondents include John Adams, Angelica Schuyler Church, Henry Clay, Elizabeth Schuyler Hamilton, John Francis Hamtramck, William Heth, John Jay, Thomas Jefferson, Rufus King, Marquis de Lafayette, Henry Lee, Pierre Charles L'Enfant, James McHenry, James Monroe, Robert Morris, Timothy Pickering, Charles C. Pinckney, Nathan Rice, John J. U. Rivardi, Philip Schuyler, Theodore Sedgwick, William Seton, William Stephens Smith, Baron von Steuben, Caleb Swan, Louis de Tousard, Robert Troup, Jeremiah Wadsworth, George Washington, James Wilkinson, and Oliver Wolcott.